For those with mild symptoms who do not seek treatment, the infection will often resolve itself given enough time (approximately 6 months). Treatment can last from 10 days to 2 months depending on the severity of the disease. The most common treatment given is a combination of quinine (650 mg of salt orally, three times daily) and clinamyacin (600 mg orally, three times daily) for 7-10 days. Other drugs have also been used in treatment with varied results. These medicines include: tetracycline, primaquine, sulfadiazine, pyrimethamine, pentamidine and atovaquone. If a patient is critically ill, chemotherapy may also be used as a treatment.
However,Azithromycin with atovaquone is an effective and well-tolerated regimen for the treatment of babesiosis. Although it is more expensive than therapy with quinine and clindamycin, this combination should be considered the first-line choice for treatment of nonlife-threatening cases of babesiosis in adults because of its lower incidence of systemic side effects.